Technology

LTS Advantages

Light Transmission Spectroscopy (LTS) is a new technology that provides nanoparticle characteristics with unprecedented performance.   LTS uses a unique, broad-band, high resolution optical analysis and optical common-mode-rejection approach to achieve unprecedented performance- far superior to DLS and NTS in speed, sensitivity, and shape differentiation.  The techology is fully covered by issued US patents.

  • Unprecedented size resolution and accuracy
  • Provides absolute particle concentration and geometry
  • Very broad size range (small molecules to cells)
  • Real time, in vitro analysis
  • Portable (unlike existing DLS and electron-microscope equipment)
  • Easily integrated into existing design and process monitoring facilities
  • No consumable, special facilities, or extensive training required
  • Interfaces via USB (proprietary software included)

LTS is a platform technology capable of many applications.  LTS has been proven to measure particles ranging from 1nm to 3000nm, including large molecules, pharmaceutical proteins, antibodies, antigen complexes, viruses, DNA, atmospheric aerosols, gold nanobeads, silver and metal oxides, polymers, bacteria, and cells.  The technology can accurately determine the size, shape, and number of nanoparticles in this critical range, significantly impacting the analysis, design, and monitoring of nanoparticles.

Platform Technology

When the same sample of whole milk is measured with Dynamic Light Scattering and Light Transmission Spectroscopy, we see that LTS can distinguish the presence of casein micelles and fat globules, and provide their density in solution - whereas DLS provides far less information
Light Transmission Spectroscopy can easily resolve and provide the absolute concentration (number density) of small micelles in a solution.  This is exceptionally important in Pharmaceutical Research and Development
Light Transmission Spectroscopy can provide the geometry of small molecules.  An example is the measurement of bovine serum albumen.  This is a first-of-a-kind result for a bench-top particle-analysis instrument